[1]李述方,王海荣.热应激对绵羊机体氧化损伤及免疫功能的影响[J].江苏农业学报,2023,(07):1606-1612.[doi:doi:10.3969/j.issn.1000-4440.2023.07.017]
 LI Shu-fang,WANG Hai-rong.Effects of heat stress on oxidative damage and immune function in sheep[J].,2023,(07):1606-1612.[doi:doi:10.3969/j.issn.1000-4440.2023.07.017]
点击复制

热应激对绵羊机体氧化损伤及免疫功能的影响()
分享到:

江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年07期
页码:
1606-1612
栏目:
综述
出版日期:
2023-10-31

文章信息/Info

Title:
Effects of heat stress on oxidative damage and immune function in sheep
作者:
李述方王海荣
(内蒙古农业大学动物科学学院/内蒙古自治区高校动物营养与饲料科学重点实验室,内蒙古呼和浩特010018)
Author(s):
LI Shu-fangWANG Hai-rong
(Inner Mongolia Key Laboratory of Animal Nutrition and Feed Science/College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018,China)
关键词:
热应激绵羊内分泌激素氧化应激信号通路免疫
Keywords:
heat stresssheependocrine hormonesoxidative stress signaling pathwayimmunity
分类号:
S858.26
DOI:
doi:10.3969/j.issn.1000-4440.2023.07.017
文献标志码:
A
摘要:
高温易引起绵羊热应激,热应激时下丘脑-垂体-肾上腺轴(The hypothalamic-pituitary-adrenal axis,HPA)和交感-肾上腺髓质轴(The sympathetico-adrenomedullary axis,SAM)兴奋,引起体内多种激素水平变化,以抵抗热应激对机体的影响;同时产生大量的活性氧(ROS)和活性氮(RNS)通过核因子E2相关因子2(Nuclear factor erythroid 2-related factor 2,Nrf2)、抗氧化反应元件(Antioxidant response element,ARE)、核转录因子kB(Nuclear factor kappa-B,NF-κB)等信号通路,调控抗氧化酶及细胞因子的表达与分泌。高温引发的热应激最终会导致绵羊生长和繁殖能力降低。本文主要阐述了热应激时绵羊体内激素水平的变化,以及氧化应激信号通路、天然免疫和适应性免疫的调控作用,以期为减轻热应激对绵羊机体氧化损伤及免疫功能影响的研究提供参考依据。
Abstract:
High temperature can cause heat stress in sheep. During heat stress,the hypothalamus-pituitary-adrenal axis (HPA) and the sympathetic-adrenomedullary axis (SAM) are excited, causing changes in various hormone levels in the body to resist the effects of heat stress. At the same time, a large amount of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced, which regulate the expression and secretion of antioxidant enzymes and cytokines through nuclear factor erythroid 2-related factor 2 (Nrf2), antioxidant response element (ARE), nuclear factor kappa-B (NF-κB) and other signaling pathways. The heat stress induced by high temperature can eventually lead to reduced growth and reproductive capacity of sheep. This article mainly described the changes of hormone levels in sheep during heat stress, as well as the regulatory effects of oxidative stress signaling pathways, natural immunity, and adaptive immunity, in order to provide reference for the study of reducing the effects of heat stress on oxidative damage and immune function in sheep.

参考文献/References:

[1]LIU H W,CAO Y,ZHOU D W. Effects of shade on welfare and meat quality of grazing sheep under high ambient temperature[J]. Journal of Animal Science,2012,90(13):4764-4770.
[2]CAROPRESE M,CILIBERTI M G,ANNICCHIARICO G,et al. Hypothalamic-pituitary-adrenal axis activation and immune regulation in heat-stressed sheep after supplementation with polyunsaturated fatty acids [J]. Journal of Dairy Science,2014,97(7):4247-4258.
[3]ZHANG Q,CONG X,LI H,et al. Puerarin ameliorates heat stress-induced oxidative damage and apoptosis in bovine Sertoli cells by suppressing ROS production and upregulating Hsp72 expression[J]. Theriogenology,2017,15(88):215-227.
[4]KANTIDZE O,VELICHKO A K,LUZHIN A V,et al. Heat stress-induced DNA damage[J]. Acta Naturae,2016,8(2):75-78.
[5]MAURYA V P,SEJAIN V,KUMAR D,et al. Impact of heat stress,nutritional restriction and combined stresses (heat and nutritional) on growth and reproductive performance of Malpura rams under semi-arid tropical environment[J]. Journal of Animal Physiology & Animal Nutrition,2016,100(5):938-946.
[6]ANDRADE-FERRAZZA R D,MOGOLLON-GARCIA H D,VALLEJO-ARISTIZABAL V H, et al. Thermoregulatory responses of Holstein cows exposed to experimentally induced heat stress[J]. Journal of Thermal Biology, 2017, 66(29): 68-80.
[7]CAIN D W,CIDLOWSKI J A. Iconography : Specificity and sensitivity of glucocorticoid signaling in health and disease[J]. Best Pract Res Clin Endocrinol Metab,2015,29(4):545-556.
[8]CWYNAR P,KOLACZ R,CZERSKI A. Effect of heat stress on physiological parameters and blood composition in Polish Merino rams[J]. Berliner Und Munchener Tierarztliche Wochenschrift,2014,127(5/6):177-182.
[9]WOJTAS K,CWYNER P, KOLACZ R. Effect of thermal stress on physiological and blood parameters in merino sheep[J]. Bulletin of the Veterinary Institute in Pulawy,2014,58(2):283-288.
[10]刘嘉莉,窦金焕,胡丽蓉,等.热应激对奶牛生理和免疫功能的影响及其机理[J].中国畜牧兽医,2018,45(1):263-270.
[11]王哲奇. 温热环境对绵羊增重性能及生理指标影响的研究[D].内蒙古:内蒙古农业大学,2020.
[12]YARAHMADI P,MIANDARE H K,FAYAZ S,et al. Increased stocking density causes changes in expression of selected stress-and immune-related genes, humoral innate immune parameters and stress responses of rainbow trout (Oncorhynchus mykiss)[J]. Fish Shellfish Immunol,2016,48(5): 43-53.
[13]MINTON J E,BLECHA F. Effect of acute stressors on endocrinological and immunological functions in lambs[J]. Journal of Animal Science,1990,68(10):3145-3151.
[14]WEST J W. Nutritional strategies for managing the heat-stressed dairy cow[J]. Journal of Animal Science,1999, 77(2): 21-35.
[15]张颖,姚旋,宋宜云,等. 甲状腺激素与代谢调控[J].生命科学,2013,25(2):176-183.
[16]PANTOJA M,ESTEVES S N,JACINTO M,et al. Thermoregulation of male sheep of indigenous or exotic breeds in a tropical environment[J]. Journal of Thermal Biology, 2017, 69: 302-310.
[17]YEN P M. Physiological and molecular basis of thyroid hormone action[J]. Physiological Reviews, 2001, 81(3): 1097-1142.
[18]OMIDA A,KHEIRIE M,SARIR H. Impact of vitamin C on concentrations of thyroid stimulating hormone and thyroid hormones in lambs under short-term acute heat stress[J]. Veterinary Science Development,2015,5(1):155-169.
[19]LU Z,CHU M,LI Q,et al. Transcriptomic Analysis Provides Novel Insights into Heat Stress Responses in Sheep[J]. Animals, 2019, 9(6):387.
[20]张灿,王之盛,彭全辉,等. 湿热应激对藏绵羊和山羊生长性能、抗氧化能力以及免疫功能的影响[J].动物营养学报,2017,29(6):2179-2187.
[21]李林,艾阳,谢正露,等. 热应激状态下泌乳奶牛通过激活GHIGF-I轴增强糖异生变化[J].中国农业科学,2016,49(15):3046-3053.
[22]MISHRA S R. Behavioural,Behavioural, physiological, neuro-endocrine and molecular responses of cattle against heat stress: an updated review[J]. Tropical Animal Health and Production, 2021, 53(3): 400-420.
[23]SETH M, BISWAS R, GANGULY S, et al. Leptin and obesity[J]. Physiology International,2022,107(4):455-468.
[24]NICOLAS-L0PEZ P, MACIAS-CRUZ U, MELLADO M,et al. Growth performance and changes in physiological, metabolic and hematological parameters due to outdoor heat stress in hair breed male lambs finished in feedlot [J]. International Journal of Biometeorology, 2021, 65(8): 1451-1459.
[25]ITOH K,MIMURA J,YAMAMOTO M. Discovery of the negative regulator of Nrf2, Keap1: a historical overview[J]. Antioxid Redox Signal, 2010, 13(11):1665-1678.
[26]胡流芳,王迎,任汝静,等. Keap1-Nrf2/ARE信号通路的抗氧化应激作用及其调控机制[J]. 国际药学研究杂志,2016,43(1):146-152,166.
[27]张轶凤,齐智利. 热应激条件下机体发生氧化应激的机制[J]. 动物营养学报,2017,29(9):3051-3058.
[28]MARTINEZ M C,ANDRIANTSITOHAINA R. Reactive nitrogen species: molecular mechanisms and potential significance in health and disease[J]. Antioxid Redox Signal, 2009, 11(3):669-702.
[29]熊款款,谭磊,王爱兵,等. Keap1-Nrf2/ARE信号通路抗氧化机制及抗氧化剂的研究进展[J].动物医学进展,2021,42(4):89-94.
[30]LEE J M,JOHNSON J A. An important role of Nrf2-ARE pathway in the cellular defense mechanism[J]. J Biochem Mol Biol,2004,37(2): 139-143.
[31]倪晓琦,陈锡威,金晓锋. E3泛素连接酶接头蛋白Keap1的研究进展[J]. 生物化学与生物物理进展, 2022,49(2):328-348.
[32]石璐璐,王哲奇,徐元庆,等. 热应激对绵羊血清免疫和抗氧化指标及相关基因相对表达量的影响[J]. 动物营养学报,2020,32(11): 5275-5284.
[33]王换换,申正杰,肖航,等. 热应激对肝脏中Keap1-Nrf2信号通路及下游基因表达的影响[J]. 南京农业大学学报,2017,40(1):151-156.
[34]GAMBHIR L,CHECKER R,SHARMA D,et al. Thiol dependent NF-κB suppression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A[J]. Toxicology and Applied Pharmacology,2015,289(2):297-312.
[35]LIOCHEV S I,FRIDOVICH I. Superoxide and iron: partners in crime [J]. IUBMB Life,1999,48(2):157-161.
[36]LINGAPPAN K. NF-κB in oxidative stress[J]. Current Opinion in Toxicology,2018,2(7):81-86.
[37]LI Q,ENGELHARDT J F. Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase[J]. Journal of Biological Chemistry,2006,281(3):1495-1505.
[38]EVANS S S,REPASKY E A,FISHER D T. Fever and the thermal regulation of immunity: The immune system feels the heat[J]. Nature Reviews Immunology,2015,15(6):335-349.
[39]PRODROMOU C. Mechanisms of Hsp90 regulation[J]. The Biochemical Journal, 2016, 473(16):2439-2452.
[40]ASEA A,KRAEFTS K, KURT-JONES E A,et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine[J]. Nature Medicine,2000,6(4):435-442.
[41]BROEME M, KRAPPMANN D, SCHEIDEREIT C. Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation[J]. Oncogene,2004,23(31): 5378-5386.
[42]唐志文,孙福昱,杨亮,等.不同饲粮条件下奶牛胃肠道中内毒素浓度与炎症反应相关关系研究进展[J].家畜生态学报,2018,39(5):6-10.
[43]OPAL S M. The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis[J]. International Journal of Medical Microbiology,2007,297(5):365-377.
[44]叶建新,林航,穆军山,等. 探讨TLR4/NF-κB信号通路在劳力性热射病大鼠脑损伤中的作用[J].解放军医学院学报,2019,40(12):1170-1173,1178.
[45]张宇,徐子洁,黄晓瑜,等. 白藜芦醇对热应激诱导的山羊小肠上皮细胞炎性反应调节作用的研究[J].畜牧兽医学报,2020,51(8):1886-1894.
[46]GU M,ZHOU X,SOHN J H,et al. NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity[J]. Nature Immunology,2021,22(2): 193-204.
[47]WU M,BIAN Q,LIU Y,et al. Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome[J]. Free Radical Biology & Medicine,2009,46(1):62-69.
[48]BAGATH M, KRISHNAN G, DEVARAJ C, et al. The impact of heat stress on the immune system in dairy cattle: A review[J]. Research in Veterinary Science, 2019,126 (10):94-102.
[49]HE S,YU Q,HE Y,et al. Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers[J]. Poultry Science,2019,98(12):6378-6387.
[50]MCEWEN D B S. Acute stress enhances while chronic stress suppresses cell-mediated immunityin vivo:a potential role for leukocyte trafficking [J]. Brain, Behavior, and Immunity,1997,11(4):286-306.
[51]SINGH K M,SINGH S,GANGULY I,et al. Evaluation of Indian sheep breeds of arid zone under heat stress condition[J]. Small Ruminant Research,2016,141(7): 113-117.
[52]RIUS A G. Heat stress-mediated activation of immune-inflammatory Pathways[J]. Antibiotics,2021,10(11):1285.
[53]KAUFMAN J D,BAILEY H R,KENNEDY A M,et al. Cooling and dietary crude protein affected milk production on heat-stressed dairy cows[J]. Livestock Science,2020,240(2): 104111.
[54]DANGI S S,BHARATI J,SAMAD H A,et al. Expression dynamics of heat shock proteins (HSP) in livestock under thermal stress[J]. Heat Shock Proteins in Veterinary Medicine and Sciences,2017,16 (12): 37-79.
[55]ARNAL M E,LALLES J P. Gut epithelial inducible heat-shock proteins and their modulation by diet and the microbiota[J]. Nutrition Reviews,2016,74(3):181-197.
[56]SAADELDIN I M,SWELUM A A,ZAKRI A M,et al. Effects of acute hyperthermia on the thermotolerance of cow and sheep skin-derived fibroblasts[J]. Animals,2020,10(4): 545.
[57]PARK H G,HAN S I,OH S Y,et al. Cellular responses to mild heat stress[J]. Cellular & Molecular Life Sciences Cmls,2005,62(1):10-23.
[58]SHI L,XU Y, MAO C,et al. Effects of heat stress on antioxidant status and immune function and expression of related genes in lambs [J]. International Journal of Biometeorology,2020,64(12): 2093-2104.
[59]彭孝坤,赵天,黄晓瑜,等. 急性热应激对山羊血液生化指标及血淋巴细胞热休克蛋白70家族基因表达的影响[J].畜牧兽医学报,2019,50(6):1219-1229.
[60]WU Y N, YAN F F, HN J Y, et al. The effect of chronic ammonia exposure on acute-phase proteins, immunoglobulin, and cytokines in laying hens[J]. Poultry Science, 2017, 96(6):1524-1530.
[61]陈浩,王纯洁,斯木吉德,等. 慢性热应激对西门塔尔牛血清酶活性和免疫功能的影响[J].中国兽医学报,2021,41(3):557-561.

相似文献/References:

[1]吴阳升,林嘉鹏,汪立芹,等.绵羊小卵泡与中卵泡转录组差异特征分析[J].江苏农业学报,2016,(04):832.[doi:10.3969/j.issn.100-4440.2016.04.019]
 WU Yang-sheng,LIN Jia-peng,WANG Li-qin,et al.Transcriptome profiling of ovine follicles during growth from small to middle antral sizes[J].,2016,(07):832.[doi:10.3969/j.issn.100-4440.2016.04.019]
[2]闫乐艳,GEORGE Mann,施振旦.利用Onapristone研究绵羊子宫内膜组织中孕酮对PGF2α分泌以及COX-2表达的影响[J].江苏农业学报,2017,(03):624.[doi:doi:10.3969/j.issn.1000-4440.2017.03.020]
 YAN Le-yan,GEORGE Mann,SHI Zhen-dan.Regulation of progesterone in PGF2α secretion and COX-2 expression by onapristone in ovine endometrial cells[J].,2017,(07):624.[doi:doi:10.3969/j.issn.1000-4440.2017.03.020]
[3]吴阳升,林嘉鹏,蒋香菊,等.绵羊FSHR基因可变剪接体的克隆、鉴定及表达分析[J].江苏农业学报,2017,(03):630.[doi:doi:10.3969/j.issn.1000-4440.2017.03.021]
 WU Yang-sheng,LIN Jia-peng,JIANG Xiang-ju,et al.Cloning, identification, and expression analysis of alternative splicing isoforms of FSHR in sheep[J].,2017,(07):630.[doi:doi:10.3969/j.issn.1000-4440.2017.03.021]
[4]唐姣玉,谢宇洁,刘兆辉,等.大蒜素对热应激湘黄鸡生产性能及营养物质代谢的影响[J].江苏农业学报,2017,(03):638.[doi:doi:10.3969/j.issn.1000-4440.2017.03.022]
 TANG Jiao-yu,XIE Yu-jie,LIU Zhao-hui,et al.Influence of allicin on growth performance and nutrient metabolism of heat-stressed Xiang yellow chicken[J].,2017,(07):638.[doi:doi:10.3969/j.issn.1000-4440.2017.03.022]
[5]李隐侠,冯小品,张莉,等.热应激前后湖羊下丘脑差异表达新基因的筛选与注释[J].江苏农业学报,2019,(02):363.[doi:doi:10.3969/j.issn.1000-4440.2019.02.017]
 LI Yin-xia,FENG Xiao-pin,ZHANG Li,et al.Screening and annotation of novel genes differentially expressed in hypothalamus before and after heat stress in Hu sheep[J].,2019,(07):363.[doi:doi:10.3969/j.issn.1000-4440.2019.02.017]
[6]卢春霞,刘长彬,万鹏程,等.绵羊ovPAG7间接竞争酶联适配体检测方法的建立与应用[J].江苏农业学报,2022,38(03):730.[doi:doi:10.3969/j.issn.1000-4440.2022.03.019]
 LU Chun-xia,LIU Chang-bin,WAN Peng-cheng,et al.Establishment and application of indirect competitive enzyme-linked aptamer assay for ovPAG7 in sheeps[J].,2022,38(07):730.[doi:doi:10.3969/j.issn.1000-4440.2022.03.019]
[7]李樊,李隐侠,舒嘉傲,等.热应激通过钙信号调控湖羊卵巢颗粒细胞凋亡和雌激素合成[J].江苏农业学报,2022,38(05):1278.[doi:doi:10.3969/j.issn.1000-4440.2022.05.015]
 LI Fan,LI Yin-xia,SHU Jia-ao,et al.Regulation of heat stress on ovarian granulosa cell apoptosis and estrogen synthesis in Hu sheep through calcium signal[J].,2022,38(07):1278.[doi:doi:10.3969/j.issn.1000-4440.2022.05.015]
[8]王泽平,沈婕,赵为民,等.热应激对猪颗粒细胞蛋白质表达谱的影响[J].江苏农业学报,2022,38(06):1569.[doi:doi:10.3969/j.issn.1000-4440.2022.06.015]
 WANG Ze-ping,SHEN Jie,ZHAO Wei-min,et al.Effects of heat stress on protein expression profiles in porcine granulosa cells[J].,2022,38(07):1569.[doi:doi:10.3969/j.issn.1000-4440.2022.06.015]
[9]孟科,赵薇,郭晨浩,等.不同品种绵羊肌内脂肪沉积相关miRNA的筛选与功能预测[J].江苏农业学报,2023,(07):1554.[doi:doi:10.3969/j.issn.1000-4440.2023.07.012]
 MENG Ke,ZHAO Wei,GUO Chen-hao,et al.Screening and functional prediction of miRNA related to intramuscular fat deposition in different sheep breeds[J].,2023,(07):1554.[doi:doi:10.3969/j.issn.1000-4440.2023.07.012]

备注/Memo

备注/Memo:
收稿日期:2022-09-13基金项目:国家自然科学基金项目(31860658);内蒙古农业大学标志性成果专项基金项目(BZCG202011)作者简介:李述方(1996-),男,山东济宁人,博士,研究方向为动物营养与饲料科学。(E-mail)lishufang0325@163.com通讯作者:王海荣,( E-mail)wanghairong97@163.com
更新日期/Last Update: 2023-11-17