[1]侯院林,张富新,李龙柱,等.羊乳中类胰岛素生长因子 I 的变化规律[J].江苏农业学报,2016,(04):843-847.[doi:10.3969/j.issn.100-4440.2016.04.020]
 HOU Yuan-lin,ZHANG Fu-xin,LI Long-zhu,et al.Variations of insulin-like growth factor I (IGF-I) in goat milk[J].,2016,(04):843-847.[doi:10.3969/j.issn.100-4440.2016.04.020]
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羊乳中类胰岛素生长因子 I 的变化规律()
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江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2016年04期
页码:
843-847
栏目:
畜牧兽医·水产养殖
出版日期:
2016-10-31

文章信息/Info

Title:
Variations of insulin-like growth factor I (IGF-I) in goat milk
作者:
侯院林张富新李龙柱于玲玲云丹雷飞燕
陕西师范大学食品工程与营养科学学院,陕西 西安 710119
Author(s):
HOU Yuan-linZHANG Fu-xinLI Long-zhuYU Ling-lingYUN DanLEI Fei-yan
College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi′an 710119, China
关键词:
羊乳类胰岛素生长因子I变化规律
Keywords:
goat milk insulin-like growth factor-I variation
分类号:
TS252.1
DOI:
10.3969/j.issn.100-4440.2016.04.020
文献标志码:
A
摘要:
为研究羊乳中类胰岛素生长因子I(IGF-I)的浓度变化,并采集富含IGF-I的羊乳原料,采用双抗体夹心酶联免疫法测定羊乳中IGF-I的浓度。在供试的4种奶山羊(萨能羊、努比羊、垚山羊和关中羊)中,关中奶山羊乳中IGF-I的浓度最高,并且所有山羊乳品中IGF-I的浓度都显著高于牛乳中的IGF-I浓度(P<0.05)。奶山羊初乳的IGF-I浓度变化较大,泌乳第1 d的羊乳中IGF-I浓度最高,随泌乳时间的延长,其浓度显著下降(P<0.05)。常乳中IGF-I浓度比较稳定,但浓度值较低。山羊日泌乳量越小,羊乳中IGF-I浓度越大。经产奶山羊乳比初产奶山羊乳具有更高的IGF-I浓度,其中,第4胎的山羊乳中IGF-I浓度最高(P<0.05)。挤奶间隔时间24 h的山羊乳比间隔12 h的山羊乳具有更高的IGF-I浓度。
Abstract:
Variations of insulin-like growth factor-I (IGF-I) in goat milk were studied for the collection of goat milk rich in IGF-I by double antibody sandwich enzyme-linked immunosorbent assay. The concentration of IGF-I in Guanzhong goat milk was the highest, and IGF-I concentrations in four goat breeds were higher than that in cow milk(P<0.05). IGF-I concentrations decreased significantly during colostrum, and stayed steady at low concentrations in its late lactation. The concentrations of IGF-I decreased with increased daily milk yield, and were higher in multiparous goat’s milk than that in its primiparous goat’s milk. The fourth parity had the highest IGF-I concentrations. The concentrations of IGF-I in the milk of goat milked twice a day were markedly lower than that milked once a day.

参考文献/References:

[1]HAENLEIN W G F. Goat milk in human nutrition[J]. Small Ruminant Research,2004, 51(2): 155-163.
[2]BAXTER R C, ZALTSMAN Z, TURTLE J R. Immunoreactive somatomedin-C/insulin-like growth factor I and its binding protein in human milk[J]. Clin Endocrinol Metab, 1984, 58: 955-959.
[3]BLUM J W, HAMMOM H. Colostrum effects on the gastrointestinal tract, and on nutritional, endocrine and metabolic parameters in neonatal calves[J]. Livestock Production Science, 2000, 66: 151-159.
[4]BLUM W F, BREIER B H. Radioimmunoassays for insulin-like growth factors and their binding proteins [J]. Growth Regulation, 1994, 4: 93-100.
[5]CAMPBELL P G, BAUMRUCKER C R. Insulin-like growth factor I and its association with binding proteins in bovine milk[J].Journal of Endocrinology,1989, 120 (1): 21-29.
[6]〖JP3〗CLEMMONS D R, UNDERWOOD L E. Nutritional regulation of IGF-1 and IGF binding proteins[J]. Annu Rev Nutr, 1991, 11: 393-412.
[7]〖JP3〗COLLIER R J, MILLER M A, MCLAUGHLIN C L, et al. Effects of recombinant bovine somatotropin (rbST) and season on plasma and milk insulin-like growth factors I (IGF-I) and II (IGF-II) in lactating dairy cows[J]. Domestic Animal Endocrinology, 2008, 35: 16-23.
[8]YOUNG G P, TARANTO T M, JONAS H A, et al. Insulin-like growth factor and the developing and mature rat small intestine: receptor and biogical vactions [J].Digestion,1990, 46: 24-252.
[9]ZHANG W,FRANKEL W L,ADAMSON W T,et al.Insulin-like growth factors 1 improves mucosal structure and function in transplanted rat small intestine[J].Transplantation,1995,59(5):755-761.
[10] ZUMKELLER W. Relationship between insulin-Like growth factorⅠand IGF-Ⅱand IGF-binding proteins in milk and the gastrointestinal tract: growth and development of the gut [J]. Journal of Pediatric Gastroenterology & Nutrition, 1992, 15(4): 357-369.
[11] GALL C. Goat breeds of the world [M]. Weikersheim: ACP-EU-CTA Technical Centre Agricultural & Rural Co-operation, 1996. 
[12] GAUTHIER S, POULIOT Y, MAUBOIS J. Growth factors from bovine milk and colostrum: composition, extraction and biological activities[J]. Dairy Science and technology, 2006, 86(2): 99-125.
[13] FRANCIS G L, UPTON F M, BALLARD F J. Insulin-like growth factors 1 and 2 in bovine colostrums: sequences and biological activities compared with those of a potent truncated form [J]. Biochemistry,1988, 251:95-103.
[14] FROESCH E R, SCHMID C, SCHWANDER J. Function of insulin-like growth factor[J]. Annual Review of Nutrition, 1991,11: 393-412.
[15] GINJALA V, PAKKANEN R. Determination of transforming growth factor-beta I (TGF-beta I) and insulin-like growth factor (IGF-I) in bovine colostrum samples[J]. Journal of Immunoassay, 1998, 19: 195-207.
[16] OH S, KIM J U, KANG S H, et al. The effects of dairy process and storage on insulin-like growth factor-I (IGF-I) content in milk and in model IGF-I-Fortified dairy products[J]. Journal of Dairy Science, 2006, 89(2): 402-409.
[17] OLLIKAINEN P, RIIHIMAKI A M. Effects of heat-treatment on insulin-like growth factor-I in bovine milk[J]. International Dairy Journal, 2012, 23: 73-78. 
[18] OLLIKAINEN P, MUURONEN K. Determination of insulin-like growth factor-I and bovine insulin in raw milk and its casein and whey fractions after microfiltration and ultrafiltration[J]. International Dairy Journal, 2013, 28: 83-87.
[19] 〖JP3〗CASTIGLIEGO L, Li X N, ARMANI A, et al. An immunoenzymatic assay to measure insulin-like growth factor 1 (IGF-1) in buffalo milk with an IGF binding protein blocking pre-treatment of the sample[J]. International Dairy Journal, 2011, 21: 421-426.
[20] SEJRSEN K, PEDERSEN L, VESTERGARRDM, et al. Biological activity of bovine milk contribution of IGF-I and IGF binding proteins[J]. Livestock Production Science, 2001, 70: 79-85.
[21] GROSVENOR C E, PICCIANO M F, BAUMRUCKER C R. Hormones and growth factors in milk[J]. Endocrine Reviews, 1992, 14(6): 71-728.
[22] HADSELL D L, BAUMRUCKER C R, KENSINGER R S. Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase[J]. Journal of Endocrinology,1993, 137: 223-230.
[23] DEHNHARD M, CLAUS R, MUNZ O, et al. Course of epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) in mammary secretions of the goat during end-pregnancy and early lactation[J]. J Vet Med,2000, 47: 533-540.
[24] ERIKSSON U, DUC G, FROESCH E R, et al. Insulin-like growth factors (IGF) I and II and IGF binding proteins (IGFBPs) in human colostrum/transitory milk during the first week postpartum: comparison with neonatal and maternal serum[J]. Biochemical and Biophysical Research Communications, 1993, 196: 267-273. 
[25] ONTSOUKA C E, BRUCKMAIER R M, BLUM J W. Fractionized milk composition during removal of colostrum and mature milk[J]. Journal of Dairy Science,2003, 86(6): 2005-2011.
[26] PAKKANEN R, AALTO J. Growth factors and antimicrobial factors of bovine colostrum[J]. International Dairy Journal, 1997, 7: 285-297. 
[27] SKAAR T C, VEGA J R, PYKE S N, et al. Changes in insulin-like growth factor-binding proteins in bovine mammary secretions associated with pregnancy and parturition[J]. Endocrinology, 1991, 131(1): 127-133.
[28] COLLIER R J, MILLER M A, HILDEBRANDT J R. Factors affecting insulin-like growth factor-I concentration in bovine milk[J]. Journal of Dairy Science, 1991, 74(9): 2905-2911.
[29] 胡志耘, 梁琪, 文鹏程, 等. 胎次及天数对牦牛初乳活性成分的影响[J], 食品工业科技, 2013(9): 94-96.
[30] WU F Y, TSAO P H, WANG D C, et al. Factors affecting growth factor activity in goat milk[J]. Journal of Dairy Science, 2006, 89(1): 1951-1955.
[31] WU F Y, ELSASSER T H. Studies on cell growth promoting activity in goat milk[J]. Journal of the Chinese Agricultural Society,1995, 33: 326-332.

备注/Memo

备注/Memo:
收稿日期:2015-11-05基金项目:“十二五”农村领域国家科技计划项目(2013BAD18B00);农业部公益性行业(农业)科研专项(201103038);陕西省农业攻关项目(2014K01-17-05).作者简介:侯院林(199-),男,陕西咸阳人,硕士研究生,研究方向:食品科学。(E-mail)891685945@qq.com通讯作者:张富新,(E-mail)fuxinzh@snnu.edu.cn
更新日期/Last Update: 2016-11-01