[1]田茂杰,马金帅,魏翔宇,等.抗氧化剂在生猪生产上的应用研究进展[J].江苏农业学报,2026,42(05):1064-1072.[doi:doi:10.3969/j.issn.1000-4440.2026.05.019]
　TIAN Maojie,MA Jinshuai,WEI Xiangyu,et al.Research progress on the application of antioxidants in pig production[J].,2026,42(05):1064-1072.[doi:doi:10.3969/j.issn.1000-4440.2026.05.019]
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抗氧化剂在生猪生产上的应用研究进展()

江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
42
期数:
2026年05期
页码:
1064-1072
栏目:
综述
出版日期:
2026-05-31

文章信息/Info

Title:
Research progress on the application of antioxidants in pig production
作者:
田茂杰1; 马金帅2; 魏翔宇1; 杨红文3; 张依裕1; 肖礼华4
(1.贵州大学动物科学学院高原山地动物遗传育种与繁殖教育部重点实验室/贵州大学香猪研究所,贵州贵阳550025;2.贵阳市黔灵山公园管理处,贵州贵阳550003;3.贵州省畜禽遗传资源管理站,贵州贵阳550001;4.遵义市畜牧渔业站,贵州遵义563000)
Author(s):
TIAN Maojie1; MA Jinshuai2; WEI Xiangyu1; YANG Hongwen3; ZHANG Yiyu1; XIAO Lihua4
(1.Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region of Ministry of Education, College of Animal Science, Guizhou University/Xiang Pig Research Institute, Guizhou University, Guiyang 550025, China;2.Management Office of Qianlingshan Park, Guiyang 550003, China;3.Guizhou Provincial Livestock and Poultry Genetic Resources Management Station, Guiyang 550001, China;4.Zunyi Animal Husbandry and Fishery Station, Zunyi 563000, China)
关键词:
抗氧化剂; 氧化应激; 生猪; 生产性能
Keywords:
antioxidant; oxidative stress; pigs; production performance
分类号:
S828
DOI:
doi:10.3969/j.issn.1000-4440.2026.05.019
文献标志码:
A
摘要:
集约化生猪养殖过程中,生猪易受环境、营养、生理及病理等多种应激因子的共同作用,导致机体氧化还原稳态失衡,诱发氧化应激,进而降低生产效益。抗氧化剂作为一种新型饲料添加剂,具备清除自由基、抑制脂质过氧化、维持细胞氧化还原稳态等生物学活性,能够缓解氧化应激引起的机体损伤,提升生猪的抗氧化能力和整体健康水平,从而有效改善生产性能,减少经济损失。本文系统阐述了抗氧化剂的分类与作用机制,综述了其在生猪生产中的应用研究进展,以期为抗氧化剂在生猪绿色健康养殖中的进一步发展提供理论依据。
Abstract:
In intensive pig breeding, pigs are susceptible to the combined effects of multiple stressors including environmental, nutritional, physiological and pathological factors, which disrupt the body’s redox homeostasis, induce oxidative stress, and consequently reduce production efficiency. As a new type of feed additive, antioxidants possess biological activities such as scavenging free radicals, inhibiting lipid peroxidation and maintaining cellular redox homeostasis. They can alleviate body damage caused by oxidative stress, improve the antioxidant capacity and overall health status of pigs, and thereby effectively enhance production performance and reduce economic losses. This paper systematically expounds the classification and action mechanisms of antioxidants, and reviews the research progress of their application in pig production, aiming to provide a theoretical basis for the further development and application of antioxidants in green and healthy pig farming.

参考文献/References:

[1]KIRAN T R, OTLU O, KARABULUT A B. Oxidative stress and antioxidants in health and disease[J]. Journal of Laboratory Medicine,2023,47(1):1-11.
[2]OKE O E, AKOSILE O A, ONI A I, et al. Oxidative stress in poultry production[J]. Poultry Science,2024,103(9):104003.
[3]LIU Z H, LI N, ZHENG Z, et al. Influence of Lonicera japonica and Radix Puerariae crude extracts on the growth performance, antioxidant capacity, and immunological functions of finishing pigs[J]. Livestock Science,2022,12(16):2109.
[4]梁姝婕,江云飞,左建军,等. 脱氧雪腐镰刀菌烯醇对畜禽的氧化损伤及外源抗氧化剂的保护作用[J]. 动物营养学报,2024,36(12):7513-7521.
[5]ARSLAN N P, DAWAR P, ALBAYRAK S, et al. Fungi-derived natural antioxidants[J]. Critical Reviews in Food Science and Nutrition,2025,65(9):1593-1616.
[6]JOMOVA K, ALOMAR S Y, ALWASEL S H, et al. Several lines of antioxidant defense against oxidative stress:antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants[J]. Archives of Toxicology,2024,98(5):1323-1367.
[7]GAO X Y, XIAO Y, LI W, et al. Synergistic effects of antioxidant blends:a comparative study on oxidative stability of lipids in feed matrices[J]. Antioxidants,2025,14(8):981.
[8]XUE Y, WANG T, LIU J P, et al. Recent trends in the development and application of nano-antioxidants for skin-related disease[J]. Antioxidants,2024,14(1):27.
[9]KIM T, KIM M, LEE J, et al. Supplementation of nano-zinc in lower doses as an alternative to pharmacological doses of ZnO in weanling pigs[J]. Journal of Animal Science and Technology,2022,64(1):70-83.
[10]IDDRISU L, DANSO F, CHEONG K L, et al. Polysaccharides as protective agents against heavy metal toxicity[J]. Foods,2024,13(6):853.
[11]KRUK J, SZYMANSKA R. Singlet oxygen oxidation products of carotenoids, fatty acids and phenolic prenyllipids[J]. Journal of Photochemistry and Photobiology B:Biology,2021,216:112148.
[12]KHAIRULLINA V, SAFAROVA I, SHARIPOVA G, et al. QSAR assessing the efficiency of antioxidants in the termination of radical-chain oxidation processes of organic compounds[J]. Molecules,2021,26(2):421.
[13]VALGIMIGLI L. Lipid peroxidation and antioxidant protection[J]. Biomolecules,2023,13(9):1291.
[14]董笑言,冉祥淼,高见红,等. 植物源天然抗氧化剂缓解家畜早期胚胎氧化应激的作用机制与应用研究进展[J]. 中国畜牧杂志,2025,61(12):54-61.
[15]GALANO A. Antioxidant activity at the molecular level:exploring ways of action and computational tools to investigate them[J]. Chemical Science,2025,16(42):19570-19593.
[16]ELGENDEY F, AL WAKEEL R A, HEMEDA S A, et al. Selenium and/or vitamin E upregulate the antioxidant gene expression and parameters in broilers[J]. BMC Veterinary Research,2022,18(1):310.
[17]ULASOV A V, ROSENKRANZ A A, GEORGIEV G P, et al. Nrf2/Keap1/ARE signaling:towards specific regulation[J]. Life Sciences,2022,291:120111.
[18]BAIRD L, YAMAMOTO M. The molecular mechanisms regulating the KEAP1-NRF2 pathway[J]. Molecular and Cellular Biology,2020,40(13):e00099-20.
[19]彭雄,李想,伍蓉蓉,等. 复方刺五加散对母猪和哺乳仔猪血清生化、抗氧化和免疫指标的影响[J]. 动物营养学报,2024,36(5):2911-2923.
[20]HE Z Z, LI C Y, XIAO X, et al. Effects of extracts of Scutellaria baicalensis and Lonicerae flos on reproductive performance, milk quality and serum indexes in sows and growth performance in suckling piglets[J]. Livestock Science,2023,275:105295.
[21]MA C, AZAD M A K, TANG W, et al. Maternal probiotics supplementation improves immune and antioxidant function in suckling piglets via modifying gut microbiota[J]. Journal of Applied Microbiology,2022,133(2):515-528.
[22]JIANG Z P, SU W F, LI W T, et al. Bacillus amyloliquefaciens 40 regulates piglet performance, antioxidant capacity, immune status and gut microbiota[J]. Animal Nutrition,2022,12:116-127.
[23]WANG K L, ZHANG H R, HAN Q J, et al. Effects of astragalus and ginseng polysaccharides on growth performance, immune function and intestinal barrier in weaned piglets challenged with lipo-polysaccharide[J]. Journal of Animal Physiology and Animal Nutrition,2020,104(4):1096-1105.
[24]张才,陈文彬,邵琦,等. 甘草多糖对哺乳仔猪健康状况和血清抗氧化能力的影响[J]. 西北农林科技大学学报(自然科学版),2022,50(2):10-16.
[25]LAURIDSEN C, SCHNHERZ A A, HJSGAARD S. Effect of maternal dietary redox levels on antioxidative status and immunity of the suckling off-spring[J]. Antioxidants,2021,10(3):478.
[26]魏盼琪,陈良清,冯卫东,等. 断奶应激对仔猪健康的影响[J]. 黑龙江畜牧兽医,2025(8):28-32.
[27]李燕,肖杰,王艳丰,等. 黄芪多糖对仔猪生长性能、免疫调节和抗氧化指标的影响[J]. 中国饲料,2025,(12):17-20.
[28]赵宇琼. 菊芋多糖对仔猪生长性能、血清及肠道抗氧化指标的影响[J]. 中国饲料,2025(14):69-72.
[29]张琼,白杨,孙超,等. 辣椒碱对断奶仔猪生长性能、免疫功能和抗氧化能力的影响[J]. 饲料工业,2025,46(17):37-41.
[30]方晶子,邬昆富,陈娟,等. 羟基蛋氨酸铁对断奶仔猪生长性能、铁吸收代谢、抗氧化功能和炎症因子的影响[J]. 饲料研究,2025,48(15):140-144.
[31]WU S N, WANG L, CUI B L, et al. Effects of vitamin A on growth performance, antioxidants, gut inflammation, and microbes in weaned piglets[J]. Antioxidants,2023,12(12):2049.
[32]O’DOHERTY J, DOWLEY A, CONWAY E, et al. Nutritional strategies to mitigate post-weaning challenges in pigs:a focus on glucans, vitamin D, and selenium[J]. Animals,2023,14(1):13.
[33]CHEN J, HUANG Z Y, CAO X H, et al. Plant-derived polyphenols as Nrf2 activators to counteract oxidative stress and intestinal toxicity induced by deoxynivalenol in swine:an emerging research direction[J]. Antioxidants,2022,11(12):2379.
[34]章利丰,孙倩,陈志荣,等. 猪精液常温保存的影响因素及抗氧化剂的应用[J]. 中国畜牧杂志,2024,60(8):7-12.
[35]王琳琳,李乐康,戴乾,等. 稀释液添加不同抗氧化剂对冷冻姜曲海猪精子质量的影响[J]. 畜牧与兽医,2024,56(11):10-15.
[36]石一凡,李晓彤,刘俊泽, 等. 维甲酸对体外热处理猪精子活力、抗氧化性能及其糖脂代谢的影响[J]. 畜牧与兽医,2023,55(11):1-10.
[37]陈志英,胡传活,唐胤晟,等. 他克林对猪精子冻后质量、抗氧化能力及糖代谢的影响[J]. 西北农业学报,2021,30(7):981-988.
[38]吕艳秋,徐曼,徐一超,等. 肉碱对冻融猪精子总抗氧化能力、抗氧化酶基因及凋亡相关基因表达的影响[J]. 中国畜牧兽医,2020,47(4):1121-1129.
[39]冯妮,陈志英,谢运法,等. 枸杞多糖对获能新鲜和冻后猪精子抗氧化能力的影响[J]. 畜牧与兽医,2021,53(9):16-20.
[40]YANG X Z, HU R Z, SHI M K, et al. Placental malfunction, fetal survival and development caused by sow metabolic disorder:the impact of maternal oxidative stress[J]. Antioxidants,2023,12(2):360.
[41]龚泽修,张星,谢凯,等. 茯苓多糖对母猪繁殖性能、仔猪生长性能及血清免疫指标、抗氧化指标的影响[J]. 饲料研究,2020,43(6):27-30.
[42]CHEN J, ZHANG Y F, YOU J M, et al. The effects of dietary supplementation of saccharomyces cerevisiae fermentation product during late pregnancy and lactation on sow productivity, colostrum and milk composition, and antioxidant status of sows in a subtropical climate[J]. Frontiers in Veterinary Science,2020,7:71.
[43]曾思静, 刘永辉, 龙静, 等. 围产期母猪饲粮补充丝氨酸对泌乳母猪和哺乳仔猪血清生化指标和抗氧化功能的影响[J]. 动物营养学报,2021,33(4):1976-1985.
[44]HUANG P F, MOU Q, YANG Y, et al. Effects of supplementing sow diets during late gestation with Pennisetum purpureum on antioxidant indices, immune parameters and faecal microbiota[J]. Veterinary Medicine and Science,2021,7(4):1347-1358.
[45]LI Q H, YANG S W, CHEN F, et al. Nutritional strategies to alleviate oxidative stress in sows[J]. Animal Nutrition,2021,9:60-73.
[46]LEE J, PARK S, PARK H, et al. Heat stress in growing-finishing pigs:effects of low protein with increased crystalline amino acids on growth, gut health, antioxidant status and microbiome[J]. Animals,2025,15(6):848.
[47]BI C P, YIN J J, YANG W, et al. Effects of dietary γ-aminobutyric acid supplementation on antioxidant status, blood hormones and meat quality in growing-finishing pigs undergoing transport stress[J]. Journal of Animal Physiology and Animal Nutrition,2020,104(2):590-596.
[48]陈博,王涤非,杨雪曦,等. 饲粮中添加角鲨烯对生长育肥猪生长性能、肉品质及抗氧化功能的影响[J]. 中国畜牧兽医,2025,52(9):4146-4154.
[49]桂文龙,张广峰,徐卫祥,等. 饲料中添加银杏叶对育肥期苏姜猪生长性能、肌内脂肪沉积及肌肉抗氧能力的影响[J]. 家畜生态学报,2025,46(7):39-46.
[50]唐佳希,邱月琴,熊云霞,等. 栀子粉对生长育肥猪生长性能、肉品质、抗氧化能力及经济效益的影响[J]. 动物营养学报,2024,36(7):4281-4292.
[51]XIONG Y X, LIU S, XIAO H, et al. Dietary stevia residue extract supplementation improves the performance and antioxidative capacity of growing-finishing pigs[J]. Journal of the Science of Food and Agriculture,2022,102(11):4724-4735.
[52]MA W F, MA Z, MAO P, et al. Effects of feed supplemented with fermented pine needles (Pinus ponderosa) on carcass quality,meat quality,and antioxidant capacity of growing-finishing pigs[J]. Foods,2025,14(12):2046.
[53]苏维发,周洪彬,蒋登湖,等. 壳寡糖对生长育肥猪生长性能、肉品质、抗氧化功能以及免疫功能的影响[J]. 动物营养学报,2021,33(5):2555-2567.
[54]ZHENG Y Y, LI Y, YU B, et al. Dietary supplementation of grape seed proanthocyanidins improves growth performance, carcass traits, and meat quality in growing-finishing pigs[J]. Animal Nutrition,2024,20:200-210.
[55]SHIN H W, JIN X H, GIM M J, et al. Inclusion of dietary nontoxic sulfur on growth performance,immune response,sulfur amino acid content and meat characteristics in growing-finishing pigs[J]. Animal Bioscience,2023,36(5):776-784.
[56]JING J Z, YIN S G, LIU Y, et al. Hydroxy selenomethionine alleviates hepatic lipid metabolism disorder of pigs induced by dietary oxidative stress via relieving the endoplasmic reticulum stress[J]. Antioxidants,2022,11(3):552.
[57]MARCHIORI M S, PAIANO D, ZATTI E, et al. Butyric acid glycerides as substitutes for antibiotics as growth enhancers in the diet of nursery piglets[J]. Research in Veterinary Science,2024,167:105110.
[58]XIONG Y X, CUI B L, HE Z T, et al. Dietary replacement of inorganic trace minerals with lower levels of organic trace minerals leads to enhanced antioxidant capacity, nutrient digestibility, and reduced fecal mineral excretion in growing-finishing pigs[J]. Frontiers in Veterinary Science,2023,10:1142054.
[59]CHEN J, WANG H K, MA Y X, et al. Effects of the methionine hydroxyl analog chelated microminerals on growth performance, antioxidant status, and immune response of growing-finishing pigs[J]. Animal Science Journal,2022,93(1):e13730.
[60]XU W W, ZHOU M, YANG Z K, et al. Organic trace elements enhance growth performance, antioxidant capacity, and gut microbiota in finishing pigs[J]. Frontiers in Veterinary Science,2024,11:1517976.

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备注/Memo

备注/Memo:
收稿日期:2026-02-02基金项目:贵州省生猪产业科技创新项目[黔农计财(2025)9号];贵州省生猪产业技术体系健康养殖功能实验室和遵义综合试验站建设项目(GZSZCYJSTX-03、GZSZCYJSTX-07)作者简介:田茂杰(2001-),男,贵州德江人,硕士研究生,主要从事单胃动物肠道营养调控研究。(E-mail)1206997073@qq.com通讯作者:张依裕,(E-mail)27292665@qq.com
更新日期/Last Update: 2026-06-17