[1]王炎,高婉宁,范益阳,等.杆状病毒-昆虫表达系统（IBEVS）表达的动物病毒样颗粒及疫苗研究进展[J].江苏农业学报,2025,(01):203-208.[doi:doi:10.3969/j.issn.1000-4440.2025.01.023]
　WANG Yan,GAO Wanning,FAN Yiyang,et al.Research progress on animal virus-like particles expressed by insect cell-baculovirus expression vector system (IBEVS) and vaccines[J].,2025,(01):203-208.[doi:doi:10.3969/j.issn.1000-4440.2025.01.023]
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杆状病毒-昆虫表达系统（IBEVS）表达的动物病毒样颗粒及疫苗研究进展()
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江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2025年01期
页码:
203-208
栏目:
综述
出版日期:
2025-01-31

文章信息/Info

Title:
Research progress on animal virus-like particles expressed by insect cell-baculovirus expression vector system (IBEVS) and vaccines
作者:
王炎1; 2; 高婉宁1; 2; 范益阳1; 玉妹2; 张德荣1; 柏家林1
(1.细胞基质疫苗关键技术与产业化教育部工程研究中心/西北民族大学生物医学研究中心/甘肃省动物细胞技术创新中心,甘肃兰州730030；2.西北民族大学生命科学与工程学院,甘肃兰州730030)
Author(s):
WANG Yan1; 2; GAO Wanning1; 2; FAN Yiyang1; YU Mei2; ZHANG Derong1; BAI Jialin1
(1.Engineering Research Center for Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education/Biomedical Research Center, Northwest Minzu University/Gansu Tech Innovation Center for Animal Cell, Lanzhou 730030, China;2.School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou 730030, China)
关键词:
病毒样颗粒; 杆状病毒-昆虫表达系统(IBEVS); 动物病毒样颗粒疫苗
Keywords:
virus-like particles; insect cell-baculovirus espression vector system (IBEVS); animal virus-like particle vaccines
分类号:
Q939.47
DOI:
doi:10.3969/j.issn.1000-4440.2025.01.023
文献标志码:
A
摘要:
杆状病毒-昆虫表达系统(IBEVS)是一种高效的外源蛋白表达平台,具有可以容纳较大的外源基因片段、蛋白质表达量较高、支持蛋白质翻译后修饰、操作简便且安全性较高等优势,已被广泛用于兽用疫苗生产。病毒样颗粒(VLP)是一种由病毒蛋白自组装形成的纳米颗粒,由于缺乏病毒遗传物质,其安全性较高。VLP表面抗原排列高度有序,可有效诱导免疫反应,是一种新型的亚单位疫苗。本文综述了 IBEVS在动物VLP疫苗中的应用现状,分析了当前IBEVS存在的问题及其解决策略,为动物VLP疫苗的进一步开发提供参考。
Abstract:
The insect cell-baculovirus expression vector system (IBEVS) is a highly efficient expression platform for exogenous proteins. It has several advantages, including the capability to accommodate relatively large exogenous gene fragments, high levels of protein expression, support for post-translational modifications of proteins, ease of operation, and high safety. Due to these advantages, it has been widely used in the production of veterinary vaccines. Virus-like particles (VLPs) are nanoscale particles that are self-assembled from viral proteins. Since they lack viral genetic material, they exhibit a high degree of safety. The surface antigens of VLPs are arranged in a highly ordered manner, which can effectively induce an immune response. VLPs are a novel type of subunit vaccine. This article provides a comprehensive review of the current application status of IBEVS in animal VLP vaccines, analyzes the existing problems of IBEVS and the corresponding strategies for solving them, and offers a reference for the further development of animal VLP vaccines.

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备注/Memo

备注/Memo:
收稿日期：2024-07-23基金项目：兰州市人才创业创新项目(2020-RC-85)；国家自然科学基金项目(31860696)；西北民族大学中央高校基本科研业务费项目(31920190003)作者简介：王炎(1998-),女,内蒙古呼和浩特人,硕士研究生,主要研究方向为动物病毒基因工程疫苗。(E-mail)wysakura616@163.com通讯作者：柏家林,(E-mail)jlbai@xbmu.edu.cn
更新日期/Last Update: 2025-02-28