[1]陈俊红,孙敬,陆雨楠,等.姜酮复合微粉对肥胖型2型糖尿病小鼠减肥及降血糖作用[J].江苏农业学报,2018,(05):1095-1099.[doi:doi:10.3969/j.issn.1000-4440.2018.05.018]
　CHEN Jun-hong,SUN Jing,LU Yu-nan,et al.Effect of zingerone compound powder on obesity and hyperglycemia in obesity type 2 diabetes[J].,2018,(05):1095-1099.[doi:doi:10.3969/j.issn.1000-4440.2018.05.018]
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姜酮复合微粉对肥胖型2型糖尿病小鼠减肥及降血糖作用()
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江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2018年05期
页码:
1095-1099
栏目:
畜牧兽医·水产养殖
出版日期:
2018-10-25

文章信息/Info

Title:
Effect of zingerone compound powder on obesity and hyperglycemia in obesity type 2 diabetes
作者:
陈俊红1; 2; 孙敬1; 2; 陆雨楠3; 马平平3; 沈伟奇3; 朱秋阳3; 戴鼎震3
（1.扬州大学比较医学研究院，江苏扬州225009；2.扬州大学兽医学院，江苏扬州225009；3.金陵科技学院动物科学与技术学院，江苏南京211169）
Author(s):
CHEN Jun-hong1; 2; SUN Jing1; 2; LU Yu-nan3; MA Ping-ping3; SHEN Wei-qi3; ZHU Qiu-yang3; DAI Ding-zhen3
(1.Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, China;2.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China;3.Institute of Animal Science and Technology, Jinling Institute of Technology, Nanjing 211169, China)
关键词:
姜酮复合微粉; 2型糖尿病; 高血糖; 肥胖
Keywords:
zingerone compound powder; type 2 diabetes; high blood glucose; obesity
分类号:
R285.5
DOI:
doi:10.3969/j.issn.1000-4440.2018.05.018
文献标志码:
A
摘要:
为了解自制的姜酮复合微粉对肥胖型2型糖尿病小鼠的减肥及降血糖作用,采用db/db小鼠为肥胖型2型糖尿病模型小鼠，给予姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ，通过葡萄糖耐量试验、胰岛素耐量试验以及组织切片技术等，观察姜酮复合微粉的作用。结果显示姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ在给药7 d后小鼠血糖值分别降至（6.20±1.27） mmol/L和（3.83±1.88） mmol/L，且用药28 d期间血糖维持稳定；服用姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ小鼠的葡萄糖水平曲线下的面积（AUC）与模型对照组相比显著降低；服用姜酮复合微粉Ⅱ小鼠腹部脂肪质量显著降低，服用姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ小鼠脂肪细胞明显缩小。说明该姜酮复合微粉具有显著降低肥胖型2型糖尿病小鼠血糖和减肥的作用。
Abstract:
In order to investigate the effect of zingerone compound powder（ZCP) on hyperglycemia and obesity in obesity type 2 diabetic mice, Db/db mice were used as model mice for obesity type 2 diabetes mellitus, and the ZCPⅠ and ZCPⅡ were given. Glucose tolerance test, insulin tolerance test and tissue slice technique were used to observe the effect of ZCP. The results showed that the blood glucose of the mice taking ZCPⅠ and ZCPⅡ decreased to (6.20±1.27) mmol/L and (3.83±1.88) mmol/L after seven days of administration, and blood glucose remained stable for four weeks. The area under the glucose level curve （AUC) of the mice taking ZCPⅠ and ZCPⅡ significantly decreased compared with that of the model control group. The weight of abdominal fat of the mice taking ZCPⅡ was significantly decreased. The size of adipocytes of the mice taking ZCPⅠ and ZCPⅡ decreased significantly. The results showed that the ZCP had a significant effect on reducing blood glucose and weight loss in obesity type 2 diabetic mice.

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备注/Memo

备注/Memo:
收稿日期：2018-07-24 基金项目：江苏省自然科学基金青年基金项目（BK20150450）；金陵科技学院“创客虚拟班”立项项目（2017CK008、2017CK009） 作者简介：陈俊红（1990-），女，安徽宿州人，博士研究生，主要从事中兽医、比较医学和实验动物学研究。（E-mail）995684500@qq.com 通讯作者：戴鼎震，（E-mail）dzdai@163.com
更新日期/Last Update: 2018-11-05