[1]常新见,万佳慧,张雨杰,等.抗猪繁殖与呼吸综合征病毒药物研究进展[J].江苏农业学报,2026,42(08):1706-1717.[doi:doi:10.3969/j.issn.1000-4440.2026.08.020]
　CHANG Xinjian,WAN Jiahui,ZHANG Yujie,et al.Research progress on anti-porcine reproductive and respiratory syndrome virus drugs[J].,2026,42(08):1706-1717.[doi:doi:10.3969/j.issn.1000-4440.2026.08.020]
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抗猪繁殖与呼吸综合征病毒药物研究进展()

江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
42
期数:
2026年08期
页码:
1706-1717
栏目:
综述
出版日期:
2026-08-31

文章信息/Info

Title:
Research progress on anti-porcine reproductive and respiratory syndrome virus drugs
作者:
常新见1; 2; 万佳慧3; 张雨杰1; 2; 宋浩志1; 2; 米春柳1; 2; 赵永强1; 2; 耿少雷1; 2; 王天云1; 2; 宋文娟4
(1.河南省重组药物蛋白表达系统国际联合实验室,河南新乡453003；2.河南医药大学生物化学与分子生物学系,河南新乡453003；3.河南医药大学第一临床学院,河南新乡453003；4.河南医药大学健康中原研究院,河南新乡453003)
Author(s):
CHANG Xinjian1; 2; WAN Jiahui3; ZHANG Yujie1; 2; SONG Haozhi1; 2; MI Chunliu1; 2; ZHAO Yongqiang1; 2; GENG Shaolei1; 2; WANG Tianyun1; 2; SONG Wenjuan4
(1.International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang 453003, China;2.Department of Biochemistry and Molecular Biology, Henan Medical University, Xinxiang 453003, China;3.First Clinical College, Henan Medical University, Xinxiang 453003, China;4.Institutes of Health Central Plains, Henan Medical University, Xinxiang 453003, China)
关键词:
猪繁殖与呼吸综合征病毒; 抗病毒策略; 作用机制; 宿主靶点; 纳米抗体
Keywords:
porcine reproductive and respiratory syndrome virus; antiviral strategy; mechanism of action; host target; nanobody
分类号:
S855.3
DOI:
doi:10.3969/j.issn.1000-4440.2026.08.020
文献标志码:
A
摘要:
猪繁殖与呼吸综合征病毒(PRRSV)具有高度的遗传变异性、复杂的免疫逃逸机制,而现有疫苗在交叉保护方面存在一定不足,使得抗病毒药物成为生产过程中预防该病毒感染的重要补充策略。本文以抗PRRSV作用机制为逻辑主线,系统综述了靶向病毒入侵(如受体阻断、内吞抑制)、靶向病毒复制[如RNA依赖性RNA聚合酶（RdRp）、蛋白酶抑制剂]、调控宿主天然免疫[如干扰素、Toll样受体/干扰素刺激因子(TLR/STING)通路激动剂]、干预宿主代谢与应激(如脂质代谢、氧化应激调控等)、基因沉默与反义寡核苷酸技术及创新生物制剂(如纳米抗体、微型蛋白等)等六大策略的研究进展。在机制层面,重点剖析了CD163清道夫受体靶向的多层次干预、病毒蛋白酶与聚合酶的抑制机制,以及天然免疫激活与炎症调控的平衡。在展望层面,提出了多靶点协同干预、老药新用系统发掘、纳米递送技术赋能天然产物和人工智能驱动药物设计等未来四大发展路径。本研究结果旨在为抗PRRSV药物的进一步研发及临床应用提供理论参考。
Abstract:
Due to the high genetic variability of porcine reproductive and respiratory syndrome virus (PRRSV) and its complex immune evasion mechanisms, existing vaccines have certain limitations in cross-protection, making antiviral drugs an important complementary strategy for preventing PRRSV infection in swine production. This paper takes the antiviral mechanism of PRRSV as its main logical thread and systematically reviews research progress on six major strategies: targeting viral entry, including receptor blocking and endocytosis inhibition; targeting viral replication, including RNA-dependent RNA polymerase (RdRp) and protease inhibitors; modulating host innate immunity, including interferon and Toll-like receptor/stimulator of interferon genes (TLR/STING) pathway agonists; intervening in host metabolism and stress, including lipid metabolism and oxidative stress regulation; gene silencing and antisense oligonucleotide technologies, and innovative biologics, including nanobodies and miniproteins. At the mechanistic level, this review provides an in-depth analysis of the multi-level intervention targeting the CD163 receptor, the inhibition mechanisms of viral proteases and polymerases, and the balance between innate immune activation and inflammatory regulation. In terms of future prospects, this paper proposes four major development pathways: multi-target synergistic intervention, systematic exploration of drug repurposing, nano-delivery-empowered natural products, and AI-driven drug design. The findings of this review can provide a theoretical reference for the further development and clinical application of antiviral drugs against PRRSV.

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备注/Memo

备注/Memo:
收稿日期：2026-05-13基金项目：河南省科技研发计划联合基金项目(252103810360、252103810366)；河南省自然科学基金项目(252300420722)；河南医药大学科研创新课题(202541)；河南医药大学组织工程与再生临床医学中心开放研究项目(2024SFYKFKT04)作者简介：常新见(1992-),男,河南商丘人,博士,讲师,主要从事PRRSV疫苗及药物相关研究。(E-mail)cxj@xxmu.edu.cn通讯作者：宋文娟,(E-mail)swj@xxmu.edu.cn
更新日期/Last Update: 2026-09-16