[1]卞婷,张珍珍,熊祺琰,等.黏蛋白MUC5AC在呼吸道病原感染中的作用及其调控机制研究进展[J].江苏农业学报,2026,42(08):1699-1705.[doi:doi:10.3969/j.issn.1000-4440.2026.08.019]
 BIAN Ting,ZHANG Zhenzhen,XIONG Qiyan,et al.Research progress on the role and regulatory mechanisms of mucin MUC5AC in respiratory pathogen infection[J].,2026,42(08):1699-1705.[doi:doi:10.3969/j.issn.1000-4440.2026.08.019]
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黏蛋白MUC5AC在呼吸道病原感染中的作用及其调控机制研究进展()

江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
42
期数:
2026年08期
页码:
1699-1705
栏目:
综述
出版日期:
2026-08-31

文章信息/Info

Title:
Research progress on the role and regulatory mechanisms of mucin MUC5AC in respiratory pathogen infection
作者:
卞婷1; 2; 张珍珍1; 2; 熊祺琰1; 2; 冯志新1; 2
(1.江苏省农业科学院兽医研究所/农业农村部兽用生物制品工程重点实验室,江苏南京210014;2.兽用生物制品<泰州>国泰技术创新中心,江苏泰州225300)
Author(s):
BIAN Ting1; 2; ZHANG Zhenzhen1; 2; XIONG Qiyan1; 2; FENG Zhixin1; 2
(1.Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences/Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture and Rural Affairs, Nanjing 210014, China;2.Guotai (Taizhou) Center of Technology Innovation for Veterinary Biologics, Taizhou 225300, China)
关键词:
黏液屏障; 黏蛋白MUC5AC; 呼吸道病原; 调控机制
Keywords:
mucus barrier; mucin MUC5AC; respiratory pathogens; regulatory mechanisms
分类号:
R183.3
DOI:
doi:10.3969/j.issn.1000-4440.2026.08.019
文献标志码:
A
摘要:
呼吸道病原体不仅严重危害养殖业,造成巨大经济损失,还可能跨种传播威胁人类健康,对全球公共卫生构成严峻威胁。呼吸道黏液屏障是机体抵御外源性感染的重要防线,黏蛋白MUC5AC作为气道黏液的核心组分,在维持呼吸道稳态和抵抗病原微生物入侵中发挥关键作用。病原体感染诱导的MUC5AC异常表达,是驱动呼吸道疾病发生的重要因素,但其调控机制尚不明确。本文系统综述了MUC5AC在抗病原微生物感染中的功能,以及呼吸道病原体诱导其异常表达的分子机制,以期为深入揭示呼吸道病原的致病机制、制定相应防治策略提供理论依据。
Abstract:
Respiratory pathogens not only inflict severe harm on the livestock industry and cause massive economic losses, but also may transmit across species to threaten human health, posing severe challenges to global public health. The respiratory mucus barrier serves as a vital defense line for the host against exogenous infections. As a core component of airway mucus, mucin MUC5AC plays a pivotal role in maintaining respiratory homeostasis and resisting the invasion of pathogenic microorganisms. Abnormal expression of MUC5AC induced by pathogenic infection is a major driver of respiratory disease onset, yet its regulatory mechanisms remain unclear. This paper systematically reviews the functions of MUC5AC in defending against pathogenic microbial infections, as well as the molecular mechanisms underlying pathogen-triggered aberrant MUC5AC expression in the respiratory tract, aiming to provide a theoretical basis for further elucidating the pathogenic mechanisms of respiratory pathogens and developing corresponding prevention and control strategies.

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备注/Memo

备注/Memo:
收稿日期:2026-01-04基金项目:国家自然科学基金项目(32500179);江苏省自然科学基金项目(SBK20250407426);江苏省科技计划专项(创新支撑计划国际科技合作)(BZ2023048)作者简介:卞婷(1990-),女,江苏连云港人,博士,助理研究员,主要从事动物呼吸道病原分子致病机制研究。(E-mail)bianting@126.com通讯作者:冯志新,(E-mail)fzxjaas@163.com
更新日期/Last Update: 2026-09-16