[1]陈永方,金文静,杨妍梅,等.DExD/H-box家族RNA解旋酶调控宿主天然免疫作用的研究进展[J].江苏农业学报,2026,42(07):1501-1512.[doi:doi:10.3969/j.issn.1000-4440.2026.07.021]
　CHEN Yongfang,JIN Wenjing,YANG Yanmei,et al.Research progress on the regulation of host innate immunity by DExD/H-box family RNA helicasesCHEN Yongfang1,2,3,JIN Wenjing1,2,3,YANG Yanmei1,4,FENG Ruofei1,2,3[J].,2026,42(07):1501-1512.[doi:doi:10.3969/j.issn.1000-4440.2026.07.021]
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DExD/H-box家族RNA解旋酶调控宿主天然免疫作用的研究进展()

江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
42
期数:
2026年07期
页码:
1501-1512
栏目:
综述
出版日期:
2026-07-31

文章信息/Info

Title:
Research progress on the regulation of host innate immunity by DExD/H-box family RNA helicasesCHEN Yongfang1,2,3,JIN Wenjing1,2,3,YANG Yanmei1,4,FENG Ruofei1,2,3
作者:
陈永方1; 2; 3; 金文静1; 2; 3; 杨妍梅1; 4; 冯若飞1; 2; 3
(1.西北民族大学生物医学研究中心/细胞基质疫苗关键技术与产业化教育部工程研究中心,甘肃兰州730030；2.西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,甘肃兰州730030；3.西北民族大学生物工程学院，甘肃兰州730030；4.西北民族大学生命科学与工程学院,甘肃兰州730030)
Author(s):
CHEN Yongfang1; 2; 3; JIN Wenjing1; 2; 3; YANG Yanmei1; 4; FENG Ruofei1; 2; 3
(1.Biomedical Research Center, Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou 730030, China;2.Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China;3.School of Bioengineering, Northwest Minzu University, Lanzhou 730030, China;4.School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou 730030, China)
关键词:
DExD/H-box家族RNA解旋酶; 病原; 天然免疫; 信号通路
Keywords:
DExD/H-box family RNA helicases; pathogeny; innate immunity; signaling pathways
分类号:
Q55
DOI:
doi:10.3969/j.issn.1000-4440.2026.07.021
文献标志码:
A
摘要:
DExD/H-box家族RNA解旋酶是宿主细胞内参与转录、RNA代谢及翻译调控的关键蛋白质,在调控宿主天然免疫中发挥重要作用。DExD/H-box家族RNA解旋酶通过识别病原相关分子模式(PAMP)或调控免疫信号通路,成为连接病原识别与免疫应答的关键因子,在天然免疫应答中形成复杂的平衡网络,从而在抗病毒、抗细菌及抗炎症反应中起到关键作用。本文综述DExD/H-box家族RNA解旋酶调控宿主天然免疫作用的最新研究进展,旨在揭示其在免疫网络中的多层面调控机制,为其作为靶点开发抗感染或免疫调节药物提供理论依据。
Abstract:
DExD/H-box family RNA helicases are key proteins in host cells involved in transcription, RNA metabolism and translation regulation, and play important roles in regulating host innate immunity. By identifying pathogen-associated molecular patterns (PAMPs) or regulating immune signaling pathways, DExD/H-box family RNA helicases serve as key factors connecting pathogen recognition and immune responses. They form a complex equilibrium network in the innate immune response, thus playing critical roles in antiviral, antibacterial and anti-inflammatory responses. This article reviews the latest research progress on the regulation of host innate immunity by DExD/H-box family RNA helicases, aiming to reveal the multi-level regulatory mechanism of DExD/H-box helicases in the immune network and provide a theoretical basis for the development of anti-infection or immunomodulatory drugs targeting these helicases.

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备注/Memo

备注/Memo:
收稿日期:2025-09-22基金项目:国家自然科学基金地区科学基金项目(32260037)；西北民族大学中央高校基本科研业务费资金项目(31920250053)；甘肃省高校研究生“创新之星”项目(2025CXZX-242)作者简介:陈永方(1997-),男,四川宜宾人,硕士研究生,主要从事病原生物学与基因工程研究。(E-mail)15283556685@163.com通讯作者:冯若飞,(E-mail)fengruofei@xbmu.edu.cn
更新日期/Last Update: 2026-08-21