参考文献/References:
[1]OMURA T, SATO R. A new cytochrome in liver microsomes[J]. J Biol Chem, 1962, 237:1375-1376.
[2]ESTABROOK R W, COOPER D Y, ROSENTHAL O. The light reversible carbon monoxide inhibitionof the steroid C21-hydroxylase system of the adrenal cortex [J]. Biochem Z, 1963, 338:741-755.
[3]WERCK-REICHHART D, FEYEREISEN R. CytochromesP450: a success story[J]. Genome Biol, 2000, 1(6):30031-30039.
[4]FU C, XIONG J, MIAO W. Genome-wide identification and characterization of cytochrome P450 monooxygenase genes in the ciliate Tetrahymena thermophila[J]. BMC Genomi, 2009, 10(208):1-21.
[5]BOSMAN A, MENDIS K N. A major transition in malaria treatment: theadoption and deployment of artemisinin-based combination therapies [J]. Am J Trop Med Hyg, 2007, 77:193-197.
[6]MISRA A, CHANOTIYA C S, GUPTA M M, et al. Characterization of cytochrome P450 monooxygenases isolated fromtrichome enriched fraction of Artemisia annua L. leaf[J]. Gene, 2012,510 (2):193-201.
[7]KOMORI A, SUZUKI M, SEKI H, et al. Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene[J]. FEBS Lett, 2013, 587 (3):278-284.
[8]NELSON D R. Cytochrome P450 nomenclature, 2004[J]. Methods Mol Biol, 2006, 320: 1-10.
[9]EDGAR R C. MUSCLE: a multiple sequence alignment method with reduced time and space complexity[J]. BMC Bioinf, 2004, 5: 113-131
[10]HALL B G. Building phylogenetic trees from molecular data with MEGA[J]. Mol Biol Evol, 2013, 30 (5):1229-1235.
[11]EMANUELSSON O, NIELSEN H, BRUNAK S, et al. Predicting subcellular localization of proteins based on their N-terminal amino acid sequence[J]. J Mol Biol, 2000, 300: 1005-1016.
[12]PETERSEN T N, BRUNAK S, VON HEIJNE G, et al. SignalP 4.0: discriminating signal peptides from transmembraneregions[J]. Nature Methods, 2011, 8:785-786.
[13]LI L, CHANG Z, PAN Z, et al. Modes of heme binding and substrate access for cytochrome P450CYP74A revealed by crystal structures of allene oxide synthase[J]. PNAS, 2008, 105 (37):13883-13888.
[14]WILLIAMS P A, COSME J, SRIDHAR V, et al. Mammalian microsomal cytochrome P450 monooxygenase:structural adaptations formembrane binding and functional diversity[J]. Mol Cell, 2000, 5(1):121-131.
[15]GOUET P, ROBERT X, COURCELLE E. ESPript/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteins[J]. Nucleic Acids Res, 2003, 31(13):3320-3323.
[16]RO D K, PARADISE E M, OUELLET M, et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast[J]. Nature, 2006, 440 (7086):940-943.
[17]TEOH K H, POLICHUK D R, REED D W, et al. Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin[J]. FEBS Lett, 2006, 580 (5):1411-1416.
[18]OLSSON M E, OLOFSSON L M, LINDAHL A L, et al. Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.[J]. Phytochemistry, 2009,70 (9):1123-1128.
[19]TING H M, WANG B, RYDEN A M, et al. The metabolite chemotype of Nicotianaben thamiana transiently expressing artemisinin biosynthetic pathway genes is a function ofCYP71AV1 type and relative gene dosage[J]. New Phytol, 2013, 199 (2):352-366.
[20]NAIR P, MISRA A, SINGH A, et al. Differentially expressed genes during contrasting growth stages of Artemisia annua for artemisinincontent[J]. PLoS ONE, 2013, 8 (4): 6037510-6037512.
[21]NELSON D R, SCHULER M A, PAQUETTE S M, et al. Comparative genomics of rice and Arabidopsis. Analysis of 727 cytochrome P450 genes and pseudogenes from a monocot and a dicot[J]. Plant Physiol, 2004, 135 (2): 756-772.
[22]NELSON D R, WERCK-REICHHART D. A P450-centric view of plant evolution[J]. Plant J, 2011, 66 (1): 194-211.
[23]GRAHAM S E, PETERSON J A. How similar are P450s and what can their differences teach us? [J]. Arch Biochem Biophys, 1999, 369(1):24-29.