[1]王婧,刁小龙,陈晓兰,等.抗菌肽Indolicidin的研究进展[J].江苏农业学报,2018,(04):949-954.[doi:doi:10.3969/j.issn.1000-4440.2018.04.034]
 WANG Jing,DIAO Xiao-long,CHEN Xiao-lan,et al.Research progress of antibacteial peptides Indolicidin[J].,2018,(04):949-954.[doi:doi:10.3969/j.issn.1000-4440.2018.04.034]
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抗菌肽Indolicidin的研究进展()
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江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2018年04期
页码:
949-954
栏目:
综述
出版日期:
2018-08-25

文章信息/Info

Title:
Research progress of antibacteial peptides Indolicidin
作者:
王婧1刁小龙2陈晓兰1王帅兵1陈海峰1张龙1
(1.江苏农牧科技职业学院,江苏泰州225300;2.中崇信诺生物科技泰州有限公司,江苏泰州225300)
Author(s):
WANG Jing1DIAO Xiao-long2CHEN Xiao-lan1WANG Shuai-bing1CHEN Hai-feng1ZHANG Long1
(1.Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, China;2.Zhongchong Sino Biotech Taizhou Co., Ltd., Taizhou 225300, China)
关键词:
抗菌肽Indolicidin衍生物作用机制
Keywords:
antimicrobial peptidesIndolicidinanaloguemechanism
分类号:
Q516
DOI:
doi:10.3969/j.issn.1000-4440.2018.04.034
文献标志码:
A
摘要:
抗菌肽是宿主先天性免疫防御系统产生的一类抵抗外界病原体感染的小分子多肽类生物活性物质,是先天性免疫的重要效应分子。抗菌肽具有的抗菌谱广、热稳定性和水溶性好等优点使其成为国内外研究热点。Indolicidin是从牛中性粒细胞胞质颗粒中分离得到的一种天然抗菌肽,具有结构小,抗菌谱广等优势,其衍生物已进入临床研究阶段。本文对Indolicidin的抗菌作用、作用机制及其构效关系等方面的研究进展进行了综述,以期为该抗菌肽的进一步研究提供资料。
Abstract:
Antimicrobial peptides produced by the host innate immune defense system are a kind of small molecule polypeptide bioactive substances, and are an important effector of innate immunity. Antimicrobial peptides have been a hot area of research at home and abroad because it has the advantages of wide antibacterial spectrum, good thermal stability and good water solubility. Indolicidin was purified from the cytoplasmic granules of bovine neutrophils. It had advantages of small structure and wide antibacterial spectrum, and its analogues were in the period of clinical studies. The antibacterial effect of Indolicidin, mechanism of action and structure-activity relationship were studies to provide information for the further research of antibacteial peptides.

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备注/Memo

备注/Memo:
收稿日期:2017-10-26 基金项目:江苏省产学研合作前瞻性联合研究项目(BY2015066-01);江苏农牧科技职业学院院级项目(NSF201504-2、NSF201606) 作者简介:王婧(1985-),女,四川绵阳人,博士,讲师,主要从事兽医药理及毒理学研究。(Tel)13951140263;(E-mail)kenhtsjj@163.com 通讯作者:张龙,(Tel)15850862592;(E-mail)longz98@163.com
更新日期/Last Update: 2018-09-04