参考文献/References:
[1]MEYERS M A, CHEN P Y, LIN A Y, et al. Biological materials:structure and mechanical properties[J]. Progress in Materials Science,2008,53(1):1-206.
[2]FERRARO V, ANTON M, SANT-LHOUTELLIER V. The “sisters” α-helices of collagen,elastin and keratin recovered from animal by-products:functionality,bioactivity and trends of application[J]. Trends in Food Science & Technology,2016,51:65-75.
[3]BRUCE FRASER R D, PARRY D A D. The structural basis of the filament-matrix texture in the avian/reptilian group of hard β-keratins[J]. Journal of Structural Biology,2011,173(2):391-405.
[4]WU P, NG C S, YAN J, et al. Topographical mapping of α- and β-keratins on developing chicken skin integuments[J]. Proceedings of the National Academy of Sciences of the United States of America,2015,112(49):E6770-E6779.
[5]GOERNER-HU X, SCOTT E L, SEEGER T, et al. Reaction stages of feather hydrolysis:factors that influence availability for enzymatic hydrolysis and cystine conservation during thermal pressure hydrolysis[J]. Biotechnology and Bioprocess Engineering,2020,25(5):749-757.
[6]SINHORINI M R, BALBINOT-ALFARO E, DE AGUIAR W, et al. Influence of process parameters and raw material on the characteristics of hydrolyzed feather meal[J]. Waste and Biomass Valorization,2021,12(5):2469-2476.
[7]金征宇. 挤压技术及其在食品饲料中的应用[M]. 无锡:江南大学, 2008.
[8]朱选,阳会军,刘当慧,等. 羽毛粉的膨化加工[J]. 饲料研究,2001,1(1):37-39.
[9]张晓辉,王志民,冯有善. 处理废弃羽毛的新工艺—膨化法[J]. 饲料研究,2000,23(11):33-35.
[10]张益奇. 羽毛角蛋白蒸汽闪爆解离与提取研究[D]. 无锡:江南大学,2016.
[11]ZHANG Y Q, ZHAO W, YANG R J. Steam flash explosion assisted dissolution of keratin from feathers[J]. ACS Sustainable Chemistry & Engineering,2015,3(9):2036-2042.
[12]ZHANG Y Q, YANG R J, ZHAO W. Improving digestibility of feather meal by steam flash explosion[J]. Journal of Agricultural and Food Chemistry,2014,62(13):2745-2751.
[13] VADILLO J, MONTES S, GRANDE H J, et al. Impact of steam-exploded feather incorporation on the biodegradation performance of renewable biocomposites[J]. Polymers,2025,17(7):910.
[14]QIN X J, XU X, GUO Y J, et al. A sustainable and efficient recycling strategy of feather waste into keratin peptides with antimicrobial activity[J]. Waste Management,2022,144:421-430.
[15]吴承燕,何爱明,张焦南,等. 碱解法优化可溶性羽毛肽工艺研究[J]. 福建轻纺,2024(3):7-10.
[16]杨波,杨光,王艳玲. 高温过氧乙酸法提取羽毛角蛋白工艺的研究[J]. 中国粮油学报,2007,22(2):97-103.
[17]NUUTINEN E M, WILLBERG-KEYRILINEN P, VIRTANEN T, et al. Green process to regenerate keratin from feathers with an aqueous deep eutectic solvent[J]. RSC Advances,2019,9(34):19720-19728.
[18]ALAHYARIBEIK S, ULLAH A. Methods of keratin extraction from poultry feathers and their effects on antioxidant activity of extracted keratin[J]. International Journal of Biological Macromolecules,2020,148:449-456.
[19]JAGADEESAN Y, MEENAKSHISUNDARAM S, SARAVANAN V, et al. Sustainable production,biochemical and molecular characterization of thermo-and-solvent stable alkaline serine keratinase from novel Bacillus pumilus AR57 for promising poultry solid waste management[J]. International Journal of Biological Macromolecules,2020,163:135-146.
[20]ABDEL-FATTAH A M, EL-GAMAL M S, ISMAIL S A, et al. Biodegradation of feather waste by keratinase produced from newly isolated Bacillus licheniformis ALW1[J]. Journal of Genetic Engineering and Biotechnology,2018,16(2):311-318.
[21]SUBATHRA DEVI C, SHANKAR R, KUMAR S, et al. Production of keratinase from a newly isolated feather degrading Bacillus cereus VITSDVM4 from poultry waste[J]. National Academy Science Letters,2018,41(5):307-311.
[22]ALAMNIE G. Production of keratinase enzyme from B. subtilis GH2 and its application in feather biodegradation[J]. Biomass Conversion and Biorefinery,2024,14(23):30113-30123.
[23]ABLIMIT N, ZHENG F Z, WANG Y, et al. Bacillus velezensis strain NA16 shows high poultry feather-degrading efficiency,protease and amino acid production[J]. Ecotoxicology and Environmental Safety,2024,278:116353.
[24]MAZOTTO A M, CEDROLA S M L, DE SOUZA E P, et al. Enhanced keratinase production by Bacillus subtilis amr using experimental optimization tools to obtain feather protein lysate for industrial applications[J]. 3 Biotech,2022,12(4):90.
[25]CALLEGARO K, BRANDELLI A, DAROIT D J. Beyond plucking:feathers bioprocessing into valuable protein hydrolysates[J]. Waste Management,2019,95:399-415.
[26]GIWU N, NNOLIM N E, NWODO U U. Keratinases produced by Chryseobacterium proteolyticum FGNn and Pseudomonas aeruginosa GNFx liberated amino acids from poultry feathers[J]. Biomass Conversion and Biorefinery,2023,15(1):687-699.
[27]BOKVELD A, NNOLIM N E, NWODO U U. Chryseobacterium aquifrigidense FANN1 produced detergent-stable metallokeratinase and amino acids through the abasement of chicken feathers[J]. Frontiers in Bioengineering and Biotechnology,2021,9:720176.
[28]方真. 嗜麦芽窄食单胞菌角蛋白酶的分子改造[D]. 无锡:江南大学, 2017.
[29]HAMMA S, BOUCHERBA N, AZZOUZ Z, et al. Statistical optimisation of Streptomyces sp. DZ 06 keratinase production by submerged fermentation of chicken feather meal[J]. Fermentation,2024,10(10):500.
[30]ABDELMOTELEB A, GONZALEZ-MENDOZA D, TZINTZUN-CAMACHO O, et al. Keratinases from Streptomyces netropsis and Bacillus subtilis and their potential use in the chicken feather degrading[J]. Fermentation,2023,9(2):96.
[31]LI Z W, LIANG S, KE Y, et al. The feather degradation mechanisms of a new Streptomyces sp. isolate SCUT-3[J]. Communications Biology,2020,3:191.
[32]SIVAKUMAR N, RAVEENDRAN S. Keratin degradation by bacteria and fungi isolated from a poultry farm and plumage[J]. British Poultry Science,2015,56(2):210-217.
[33]BOHACZ J. Biodegradation of feather waste keratin by a keratinolytic soil fungus of the genus Chrysosporium and statistical optimization of feather mass loss[J]. World Journal of Microbiology and Biotechnology,2016,33(1):13.
[34]KIM J D. Purification and characterization of a keratinase from a feather-degrading fungus,Aspergillus flavus strain K-03[J]. Mycobiology,2007,35(4):219-225.
[35]GAHATRAJ I, ROY R, PHUKAN B C, et al. Isolation,identification,and molecular characterization of potential keratinolytic fungus sp. from Southern Assam:relevance to poultry wastes and its biological management[J]. Archives of Microbiology,2024,206(3):99.
[36]MOZEJKO M, BOHACZ J. Optimization of conditions for feather waste biodegradation by geophilic Trichophyton ajelloi fungal strains towards further agricultural use[J] . International Journal of Environmental Research And Public Health，2022，31，19(17):10858.
[37]THADIYAN V, SHARMA V, GUPTA R. Keratinase and its diverse applications[J]. 3 Biotech,2025,15(6):151.
[38]WANG Z, CHEN Y Z, YAN M C, et al. Research progress on the degradation mechanism and modification of keratinase[J]. Applied Microbiology and Biotechnology,2023,107(4):1003-1017.
[39]KSHETRI P, ROY S S, CHANU S B, et al. Valorization of chicken feather waste into bioactive keratin hydrolysate by a newly purified keratinase from Bacillus sp. RCM-SSR-102[J]. Journal of Environmental Management,2020,273:111195.
[40]YAN X, ZHOU H Q, WANG R L, et al. Biochemical characterization and molecular docking of a novel alkaline-stable keratinase from Amycolatopsis sp. BJA-103[J]. International Journal of Biological Macromolecules,2025,295:139669.
[41]WANG T W, LIANG C, XIAO S, et al. A thermostable aluminum-tolerant protease produced by feather-degrading Bacillus thuringiensis isolated from tea plantation[J]. Protein and Peptide Letters,2021,28(5):563-572.
[42]YAHAYA R S R, NORMI Y M, PHANG L Y, et al. Molecular strategies to increase keratinase production in heterologous expression systems for industrial applications[J]. Applied Microbiology and Biotechnology,2021,105(10):3955-3969.
[43]GHAFFAR I, IMTIAZ A, HUSSAIN A, et al. Microbial production and industrial applications of keratinases:an overview[J]. International Microbiology,2018,21(4):163-174.
[44]FANG Z, ZHANG J, LIU B H, et al. Cloning,heterologous expression and characterization of two keratinases from Stenotrophomonas maltophilia BBE11-1[J]. Process Biochemistry,2014,49(4):647-654.
[45]LI K T, LI G H, LIANG Y Y, et al. Structural and enzymatic characterization of a novel metallo-serine keratinase KerJY-23[J]. International Journal of Biological Macromolecules,2024,260:129659.
[46]FANG Z, SHA C, PENG Z, et al. Protein engineering to enhance keratinolytic protease activity and excretion in Escherichia coli and its scale-up fermentation for high extracellular yield[J]. Enzyme and Microbial Technology,2019,121:37-44.
[47]LAI Y H, WU X Y, ZHENG X L, et al. Insights into the keratin efficient degradation mechanism mediated by Bacillus sp. CN2 based on integrating functional degradomics[J]. Biotechnology for Biofuels and Bioproducts,2023,16(1):59.
[48]LIN X, WONG S L, MILLER E S, et al. Expression of the Bacillus licheniformis PWD-1 keratinase gene in B. subtilis[J]. Journal of Industrial Microbiology and Biotechnology,1997,19(2):134-138.
[49]YONG B, FEI X T, SHAO H H, et al. Recombinant expression and biochemical characterization of a novel keratinase BsKER71 from feather degrading bacterium Bacillus subtilis S1-4[J]. AMB Express,2020,10(1):9.
[50]LI K T, LI G H, PENG S Y,et al. Effective biodegradation on chicken feather by the recombinant KerJY-23 Bacillus subtilis WB600:a synergistic process coupled by disulfide reductase and keratinase[J]. International Journal of Biological Macromolecules,2023,253:127194.
[51]YANG Z L, ZHANG Z S. Engineering strategies for enhanced production of protein and bio-products in Pichia pastoris:a review[J]. Biotechnology Advances,2018,36(1):182-195.
[52]LIU B H, ZHANG J, GU L, et al. Comparative analysis of bacterial expression systems for keratinase production[J]. Applied Biochemistry and Biotechnology,2014,173(5):1222-1235.
[53]YANG L, WANG H, LYU Y, et al. Construction of a rapid feather-degrading bacterium by overexpression of a highly efficient alkaline keratinase in its parent strain Bacillus amyloliquefaciens K11[J]. Journal of Agricultural and Food Chemistry,2016,64(1):78-84.
[54]KEROUAZ B, JAOUADI B, BRANS A, et al. Purification and biochemical characterization of two novel extracellular keratinases with feather-degradation and hide-dehairing potential[J]. Process Biochemistry,2021,106:137-148.
[55]GONG J S, WANG Y, ZHANG D D, et al. Biochemical characterization of an extreme alkaline and surfactant-stable keratinase derived from a newly isolated actinomycete Streptomyces aureofaciens K13[J]. RSC Advances,2015,5(31):24691-24699.
[56]MWANZA E P, VAN DER WESTHUIZEN W A, BOUCHER C E, et al. Heterologous expression and characterisation of a keratinase produced by Chryseobacterium carnipullorum[J]. Protein Expression and Purification,2021,186:105926.
[57]WANG L, ZHOU Y, HUANG Y, et al. Cloning and expression of a thermostable keratinase gene from Thermoactinomyces sp. YT06 in Escherichia coli and characterization of purified recombinant enzymes[J]. World Journal of Microbiology and Biotechnology,2019,35(9):135.
[58]PENG Z, ZHANG J, DU G C, et al. Keratin waste recycling based on microbial degradation:mechanisms and prospects[J]. ACS Sustainable Chemistry & Engineering,2019,7(11):9727-9736.
[59]RAMNANI P, SINGH R, GUPTA R. Keratinolytic potential of Bacillus licheniformis RG1:structural and biochemical mechanism of feather degradation[J]. Canadian Journal of Microbiology,2005,51(3):191-196.
[60]BOCKLE B, MULLER R. Reduction of disulfide bonds by Streptomyces pactum during growth on chicken feathers[J]. Applied and Environmental Microbiology,1997,63(2):790-792.
[61]LIANG S, DENG J J, ZHANG M S, et al. Promotion of feather waste recycling by enhancing the reducing power and keratinase activity of Streptomyces sp. SCUT-3[J]. Green Chemistry,2021,23(14):5166-5178.
[62]张宝玉,彭政,张娟,等. 基于二硫键还原酶异源表达与优化的羽毛废弃物双酶协同降解及应用[J]. 食品与发酵工业,2023,49(6):42-49.
[63]PEI X D, LI F, YUE S Y, et al. Production and characterization of novel thermo- and organic solvent-stable keratinase and aminopeptidase from Pseudomonas aeruginosa 4-3 for effective poultry feather degradation[J]. Environmental Science and Pollution Research,2023,30(2):2480-2493.
[64]JI X M, YANG J H, CHEN J, et al. A synergistic catalytic system of keratinase and disulfide reductase for the bioconversion of feather wastes to feed alternative protein[J]. Food Bioscience,2024,59:104219.
[65]张荣,凌晓宁,李昆太. 微生物降解角蛋白机制及角蛋白酶应用研究进展[J]. 生物灾害科学,2020,43(4):331-337.
[66]ELLEBOUDY N S, TRABIK Y A, ABOULWAFA M M. Optimization of feather degradation by a Bacillus thuringiensis isolate using response surface methodology and investigation of the feather protein hydrolysate structure[J]. Biotechnology and Applied Biochemistry,2023,70(3):1258-1269.
[67]HONG C, ZHU J Q, ZHAO Y M, et al. Effects of dual-frequency slit ultrasound on the enzymolysis of high-concentration hydrolyzed feather meal:biological activities and structural characteristics of hydrolysates[J]. Ultrasonics Sonochemistry,2022,89:106135.
[68] KERGET M, COLNIK M, ZEMLJIC L F, et al. Efficient and green isolation of keratin from poultry feathers by subcritical water[J]. Polymers,2023,15(12):2658.
[69]STIBOROVA H, BRANSKA B, VESELA T, et al. Transformation of raw feather waste into digestible peptides and amino acids[J]. Journal of Chemical Technology & Biotechnology,2016,91(6):1629-1637.
[70]JIN H S, PARK S Y, KIM J Y, et al. Fluorescence-based quantification of bioactive keratin peptides from feathers for optimizing large-scale anaerobic fermentation and purification[J]. Biotechnology and Bioprocess Engineering,2019,24(1):240-249.
[71]ZHANG J, SU C, KONG X L, et al. Directed evolution driving the generation of an efficient keratinase variant to facilitate the feather degradation[J]. Bioresources and Bioprocessing,2022,9(1):38.
[72]OSUNBAMI O T, ADEOLA O. Energy value of hydrolyzed feather meal and flash-dried poultry protein for broiler chickens and pigs[J]. Journal of Animal Science,2022,100(3):1-8 .
[73]YEH R H, HSIEH C W, CHEN K L. Two-stage fermented feather meal enhances growth performance and amino acid digestibility in broilers[J]. Fermentation,2023,9(2):128.
[74]PAN L, MA X K, WANG H L, et al. Enzymatic feather meal as an alternative animal protein source in diets for nursery pigs[J]. Animal Feed Science and Technology,2016,212:112-121.
[75]HUANG H J, LEE Y S, WENG B C, et al. Two-stage fermented feather meal-soybean meal product improves the performance and immunity of lactating sows and piglets[J]. Fermentation,2023,9(2):82.
[76]OLIVA-TELES A, GONCALVES P. Partial replacement of fishmeal by brewers yeast (Saccharomyces cerevisiae) in diets for sea bass (Dicentrarchus labrax) juveniles[J]. Aquaculture,2001,202(3/4):269-278.
[77]KE K M, SUN Y J, HE T T, et al. Effects of feather hydrolysates generated by probiotic Bacillus licheniformis WHU on gut microbiota of broiler and common carp[J]. Journal of Microbiology,2024,62(6):473-487.
[78]PACHECO G F E, PEZZALI J G, DE MELLO KESSLER A, et al. Inclusion of exogenous enzymes to feathers during processing on the digestible energy content of feather meal for adult dogs[J]. Revista Brasileira de Zootecnia,2016,45(6):288-294.
[79]BALOUEI F, STEFANON B, ARMONE R, et al. Nutritional and microbiome effects of a partial substitution of poultry meat with hydrolyzed feather meal in dog diets[J]. Microorganisms,2025,13(1):121.
[80]COLLA G, NARDI S, CARDARELLI M, et al. Protein hydrolysates as biostimulants in horticulture[J]. Scientia Horticulturae,2015,196:28-38.
[81]BHANGE K, CHATURVEDI V, BHATT R. Ameliorating effects of chicken feathers in plant growth promotion activity by a keratinolytic strain of Bacillus subtilis PF1[J]. Bioresources and Bioprocessing,2016,3(1):13.
[82]GODA D A, EL-GAMAL E H, RASHAD M, et al. The optimization of calcareous soil cation exchange capacity via the feather hydrolysate and N-P fertilizers integration[J]. Scientific Reports,2025,15:4676.
[83]ADELERE I A, LATEEF A. Application of bacterial feather hydrolysates as biofertilizers in growing leafy vegetables:yield,nutritional,phytochemical,antioxidant and hepatoprotective profiles[J]. Clean Technologies and Environmental Policy,2023,25(9):2951-2969.
[84]DEVI S, KESTA K, SHARMA M, et al. Effect of chicken feather hydrolysate on growth and yield of French bean[J]. Waste and Biomass Valorization,2024,15(9):5387-5414.
[85]曹亮亮,王康,马婧,等. 酸解羽毛粉代替蛋白胨研制新型细菌培养基[J]. 微生物学通报,2014,41(11):2353-2361.
[86]YEO I, LEE Y J, SONG K, et al. Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1[J]. Journal of Biotechnology,2018,271:17-25.
[87]LIU P. Extraction of poultry feather keratin and its application as drug delivery systems for precise tumor chemotherapy[J]. Food Bioscience,2024,61:104810.
[88]MU B N, YU X Q, YANG Y Q. Continuously spun biocomposite fibers from feather keratin and chitin with better toughness than wool via enhanced protein unfolding and conformation organization[J]. Chemical Engineering Journal,2024,482:148850.
[89] MOKREJ P, HUTTA M, PAVLACKOV J, et al. Preparation of keratin hydrolysate from chicken feathers and its application in cosmetics[J]. Journal of Visualized Experiments,2017(129):e56254.
[90]AMANO K, OHTA S, HOSAKA Y, et al. LB1785 Keratide,a peptide derived from waterfowl feather keratin hydrolysate,activates TGF-β and JAK/STAT pathways via ERK MAPK signaling to promote skin function and wound healing[J]. Journal of Investigative Dermatology,2023,143(9):B33.
[91]WANG J, HAO S L, LUO T T, et al. Feather keratin hydrogel for wound repair:preparation,healing effect and biocompatibility evaluation[J]. Colloids and Surfaces B:Biointerfaces,2017,149:341-350.