[1]崔兆康,苏琦,张建丽,等.微塑料对生物体生殖发育的毒性作用及其分子机制研究进展[J].江苏农业学报,2026,42(06):1116-1124.[doi:doi:10.3969/j.issn.1000-4440.2026.06.004]
　CUI Zhaokang,SU Qi,ZHANG Jianli,et al.Research progress on the toxic effects of microplastics on the reproductive development of organisms and their molecular mechanisms[J].,2026,42(06):1116-1124.[doi:doi:10.3969/j.issn.1000-4440.2026.06.004]
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微塑料对生物体生殖发育的毒性作用及其分子机制研究进展()

江苏农业学报[ISSN:1006-6977/CN:61-1281/TN]

卷:
42
期数:
2026年06期
页码:
1116-1124
栏目:
微塑料的环境效应和健康影响专题
出版日期:
2026-06-30

文章信息/Info

Title:
Research progress on the toxic effects of microplastics on the reproductive development of organisms and their molecular mechanisms
作者:
崔兆康1; 苏琦2; 张建丽1; 张俊1; 苗义龙2; 王慧利1
(1.江苏省农业科学院畜牧研究所/江苏省畜禽精准育种工程研究中心/农业农村部种养结合重点实验室,江苏南京210014;2.南京农业大学动物科技学院,江苏南京210095)
Author(s):
CUI Zhaokang1; SU Qi2; ZHANG Jianli1; ZHANG Jun1; MIAO Yilong2; WANG Huili1
(1.Institute of Animal Science, Jiangsu Academy of Agricultural Sciences/Jiangsu Province Engineering Research Center for Precision Animal Breeding/Key Laboratory of Crop and Animal Integrated Farming, Ministry of Agriculture and Rural Affairs, Nanjing 210014, China;2.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China)
关键词:
微塑料; 生殖发育毒性; 毒理机制; 解毒途径; 经济动物
Keywords:
microplastics; reproductive and developmental toxicity; toxicological mechanisms; detoxification pathways; economic animals
分类号:
X171.5
DOI:
doi:10.3969/j.issn.1000-4440.2026.06.004
文献标志码:
A
摘要:
微塑料在环境中持续降解,对全球生态及生物健康构成了严重威胁。除累积于各生态系统外,微塑料可通过多种途径进入生物体,对动物神经系统、呼吸系统及消化系统产生不良影响。已有研究结果表明,微塑料具有生殖发育毒性,能干扰配子发生、胚胎发育及子代健康。本文综述了微塑料在不同生物模型中的生殖发育毒性研究进展,重点剖析了氧化应激、炎症反应、内分泌干扰及表观遗传调控等潜在分子机制。此外,本文对基于抗氧化剂、中草药及益生菌等的毒性缓解策略的开发与应用进行了展望。本文旨在为微塑料诱发的生殖发育毒性的毒理研究及环境风险评估提供科学参考。
Abstract:
Microplastics continuously degrade in the environment, posing a serious threat to global ecology and biological health. Besides accumulating in various ecosystems, microplastics can enter organisms through multiple pathways, adversely affecting the nervous, respiratory, and digestive systems of animals. Existing studies have confirmed that microplastics exhibit reproductive and developmental toxicity and can interfere with gametogenesis, embryonic development, and offspring health. We reviewed the research progress on the reproductive and developmental toxicity of microplastics in different biological models, with a focus on analyzing potential molecular mechanisms such as oxidative stress, inflammatory response, endocrine disruption, and epigenetic regulation. Furthermore, we discussed the prospects for the development and application of toxicity mitigation strategies, including antioxidants, Chinese herbal medicines, and probiotics. This paper aims to provide a scientific reference for the study of the reproductive and developmental toxicology of microplastics and environmental risk assessment.

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备注/Memo

备注/Memo:
收稿日期：2026-03-11基金项目：国家自然科学基金项目(32402759)作者简介：崔兆康(1991-),男,山东日照人,博士，助理研究员,主要从事卵母细胞成熟调控和质量控制的研究。(E-mail)cuizhaokang@jaas.ac.cn通讯作者：苗义龙,(E-mail)miaoyilong@njau.edu.cn；王慧利,(E-mail)wanghuili@jaas.ac.cn
更新日期/Last Update: 2026-07-15